There are important differences between airborne transmission and transmission via respiratory secretions. While we do not know with certainty what role direct physical contact has versus the role of respiratory secretions, in instances where people who have monkeypox have travelled on airplanes, no known cases of monkeypox occurred in people seated around them, even on long international flights. Most cases of monkeypox report close contact with an infectious person. Prior studies of monkeypox outbreaks show that spread of monkeypox virus by respiratory secretions appears uncommon. We continue to study other possible modes of transmission, such as through semen. In the current monkeypox outbreak, we know that those with disease generally describe close, sustained physical contact with other people who are infected with the virus. It may also spread through respiratory secretions when people have close, face-to-face contact. Monkeypox spreads through direct contact with body fluids or sores on the body of someone who has monkeypox, or with direct contact with materials that have touched body fluids or sores, such as clothing or linens. It is not known to linger in the air and is not transmitted during short periods of shared airspace. Monkeypox virus is a completely different virus than the viruses that cause COVID-19 or measles.